Patient Assistance
SAFETY NET® Foundation 
The SAFETY NET® Foundation is a well-established patient assistance program that provides access to Amgen products for qualifying patients. Through a simple registration and enrollment process, patients who qualify for free drug donations through the Foundation can receive needed Amgen products through their enrolled provider.

Who is eligible? How can patients apply?

Certain uninsured or underinsured patients with limited financial resources are eligible for the SAFETY NET® Foundation. These patients must meet insurance and income eligibility criteria. To determine if a patient may be eligible, use the eligibility screener: Patients can apply for assistance through a sponsoring health care professional. To discuss enrollment, patients and providers may call the toll-free number above.

When calling the SAFETY NET® Foundation, please be prepared with the following information:

Provider Information
  • Provider name
  • Name of contact person
  • Address of contact person
  • Telephone/fax numbers of contact person

Patient Information*
  • Written patient's authorization to disclose patient identifiable and medical information
  • Patient name
  • Social Security number
  • Duration of therapy
  • Patient's annual family income
  • Insurance information for all insurance plans in which the patient participates, including name of insurer, pending insurance coverage (and anticipated effective date), and any denied claim (with reason[s] for denial).
  • Download Patient Authorization Form (PDF, 45 Kb)
  • You need to have Adobe® Acrobat® installed to view PDF files. If you do not have Acrobat® Reader®, you can download it for free from Adobe® website.

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*Before providing any patient-identifiable information (including name, social security number, address, ZIP Code, insurance policy number, or employer) to the SAFETY NET® Foundation staff, the provider must have the patient's written authorization to disclose such information for purposes of seeking reimbursement assistance or enrollment in the SAFETY NET® Foundation and provide such written authorization to the Reimbursement Connection®.

Amgen reserves the right to approve or deny any SAFETY NET® Foundation application or to modify or discontinue the program with respect to any patient or provider, or in its entirety, at any time. Amgen reserves the right to make an independent determination of eligibility in all cases.


The information provided in this section is of a general nature and for informational purposes only. Coding and coverage policies change periodically and often without warning. The responsibility to determine coverage and reimbursement parameters and appropriate coding for a particular patient and/or procedure is always the responsibility of the provider or physician. The information provided in this section should in no way be considered a guarantee of coverage or reimbursement for any product or service.

Aranesp® (darbepoetin alfa) Indications and Important Safety Information including Boxed WARNINGS

Indications

Aranesp® is indicated for the treatment of anemia:

  • associated with chronic renal failure (CRF), including patients on dialysis and patients not on dialysis.
  • in patients with non-myeloid malignancies where anemia is due to the effect of concomitantly administered chemotherapy. Aranesp® use has not been demonstrated in controlled clinical trials to improve symptoms of anemia, quality of life, fatigue, or patient well-being. Aranesp® is not indicated for use in patients receiving hormonal agents, therapeutic biologic products, or radiotherapy unless receiving concomitant myelosuppressive chemotherapy.

Important Safety Information including Boxed WARNINGS

WARNINGS: INCREASED MORTALITY, SERIOUS CARDIOVASCULAR and THROMBOEMBOLIC EVENTS, and TUMOR PROGRESSION

Renal failure: Patients experienced greater risks for death and serious cardiovascular events when administered erythropoiesis-stimulating agents (ESAs) to target higher versus lower hemoglobin levels (13.5 vs. 11.3 g/dL; 14 vs. 10 g/dL) in two clinical studies. Individualize dosing to achieve and maintain hemoglobin levels within the range of 10 to 12 g/dL.

Cancer:

  • ESAs shortened overall survival and/or time-to-tumor progression in clinical studies in patients with breast, non-small cell lung, head and neck, lymphoid, and cervical cancers when dosed to target a hemoglobin of > 12 g/dL.
  • The risks of shortened survival and tumor progression have not been excluded when ESAs are dosed to target a hemoglobin of < 12 g/dL.
  • To minimize these risks, as well as the risk of serious cardio- and thrombovascular events, use the lowest dose needed to avoid red blood cell transfusions.
  • Use only for treatment of anemia due to concomitant myelosuppressive chemotherapy.
  • Discontinue following the completion of a chemotherapy course.

Aranesp® is contraindicated in patients with uncontrolled hypertension. Patients with chronic renal failure (CRF) experienced greater risks for death and serious cardiovascular events when administered erythropoiesis-stimulating agents (ESAs) to target higher versus lower hemoglobin levels in two clinical studies. Patients with CRF and an insufficient hemoglobin response to ESA therapy may be at even greater risk for cardiovascular events and mortality than other patients. Aranesp® and other ESAs increased the risks for death and serious cardiovascular events in controlled clinical trials of patients with cancer. These events included myocardial infarction, stroke, congestive heart failure, and hemodialysis vascular access thrombosis. A rate of hemoglobin rise of > 1 g/dL over 2 weeks may contribute to these risks. Seizures have occurred in patients with CRF participating in Aranesp® clinical trials.

Cases of pure red cell aplasia (PRCA) and of severe anemia, with or without other cytopenias, associated with neutralizing antibodies to erythropoietin have been reported in patients treated with Aranesp®. This has been reported predominantly in patients with CRF receiving Aranesp® by subcutaneous administration. A sudden loss of response to Aranesp®, accompanied by severe anemia and low reticulocyte count, should be evaluated. If anti-erythropoietin antibody-associated anemia is suspected, withhold Aranesp® and other erythropoietic proteins. Aranesp® should be permanently discontinued in patients with antibody-mediated anemia. Patients should not be switched to other erythropoietic proteins as antibodies may cross-react.

The most commonly reported side effects in clinical trials in patients with CRF were infection, hypertension, hypotension, myalgia, headache, and diarrhea. The most commonly reported side effects in clinical trials in patients with anemia due to concomitant chemotherapy were fatigue, edema, nausea, vomiting, diarrhea, fever and dyspnea.

Please click here for accompanying Aranesp® package insert for full prescribing information, including Boxed WARNINGS.

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