Xiaoting is a cellular immunologist in toxicology research, with expertise in T cell biology, cytokines and translational immunology. She currently leads the Translational Immunobiology group in Translational Safety & Bioanalytical Sciences at Amgen. Xiaoting’s group has developed many in vitro immune assays to evaluate target expression, predictive safety, functional assessment of the drug candidates and the PD biomarkers for toxicology studies. In addition, her group is working on comparative studies of the immune and hematopoietic systems in non-clinical species and human by single cell RNA sequencing, cytof and flow analysis. The group is also exploring in vitro organoid culture models to answer safety related questions.
Featured Publications
Frank B, Wei YL, Kim K, Guerrero A, Lebrec H, Balazs M, Wang X. (2018) Development of a BiTE®-mediated CD8+ Cytotoxic T-lymphocyte Activity Assay to Assess Immunomodulatory Potential of Drug Candidates in Cynomolgus Macaque. Journal of Immunotoxicology, 15:1, 119-125 https://pubmed.ncbi.nlm.nih.gov/30241454/
Wang X, Lebrec H. (2017) Immunophenotyping: Application to Safety Assessment. Toxicologic Pathology. 45: 1004-1011 https://pubmed.ncbi.nlm.nih.gov/29096594/
Wang X, Wong K, Ouyang W, Rutz S. (2017) Book chapter: Targeting IL-10 Family Cytokines for the Treatment of Human Diseases. Cytokines: From Basic Mechanisms of Cellular Control to New Therapeutics, Cold Spring Harbor Perspectives in Biology https://pubmed.ncbi.nlm.nih.gov/29038121/
Kolumam G, Wu X, Lee WP, Hackney JA, Zavala-Solorio J, Gandham V, Danilenko DM, Arora P, Wang X*, Ouyang W*. (2017) IL-22R Ligands IL-20, IL-22, and IL-24 Promote Wound Healing in Diabetic db/db Mice. PLoS One. 26;12(1) *Corresponding author https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5268431/
Wang X*, Ota N*, Manzanillo P, Kates L, Zavala-Solorio J, Eidenschenk C, Zhang J, Lesch J, Lee WP, Ross J, Diehl L, van Bruggen N, Kolumam G*, Ouyang W. (2014). Interleukin-22 alleviates metabolic disorders and restores mucosal immunity in diabetes. Nature. 514: 237-41. * Equal contribution https://pubmed.ncbi.nlm.nih.gov/25119041/
Education
Postdoctoral Fellowship, La Jolla Institute for Allergy and Immunology
Ph.D., Immunology & Virology Program, University of Massachusetts Medical School, MA
B.S., Biochemistry and Molecular Biology, Peking University, Beijing, China