Multispecific medicines have the potential to radically alter our concept of how drugs work and pave the way for new therapies. We built our Induced Proximity Platform to identify multispecific molecules that induce proximity to enable the modulation of a target. These multispecifics harness the power of cell biology by using a built-in "address label" to concentrate their impact where it is most needed, or by acting as "molecular matchmakers" to link a disease-causing target to potent natural mechanisms in our bodies that act upon that target. We believe multispecifics and other modalities are leading the next wave of drug discovery.

What are multispecific medicines?

Multispecifics harness nature's matchmakers by bringing a target close to an "effector" found naturally in our cells that can act on that target.

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Undruggable


The Undruggable Podcast

Hosted by Ray Deshaies

Senior Vice President, Global Research at Amgen

Beginning with the introduction of aspirin at the start of the 20th century, there have been three major waves of innovation in drug discovery. Science has made incredible breakthroughs in treating and curing disease, and yet 85% of disease targets are still considered undruggable, which represents an ongoing barrier to discovering medicines for complex diseases like cancer and autoimmune conditions.

In this five-part series, Ray Deshaies, who has spent decades in academic research and is a senior vice president of Global Research at Amgen, hosts conversations with leading scientists to take a deep dive into the most promising new innovations to treat disease as we enter a fourth wave of innovation.

Listen in to learn how the current wave of discovery, led by new types of multispecific medicines, has the potential to radically alter our concept of how drugs can work and pave the way for new solutions.

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There's a place for you

Multispecific drugs currently comprise approximately 60% of Amgen's preclinical pipeline, and we believe this is one of the most exciting areas of research and development. We have earned numerous recognitions as a great place to work, including being named one of America's Best Large Employers by Forbes magazine, as well as one of the World's 25 Best Workplaces™ by Fortune and Great Place to Work®.

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