Summary of Data^(a)

(a)

Reported columns in the Summary of Data table represent the following information

• 2007 – Base year of Amgen's 1st Sustainability Plan 2008-2012 and of our overall sustainability efforts
• 2012 – Base year of Amgen's 2nd Sustainability Plan 2013-2019
• 2019 – Base year of Amgen's 3rd and current Sustainability Plan (2020-2027)
• 2020 – Annual data: 1st year of 2020-2027 Sustainability Plan
• 2021 – Annual data: 2nd year of 2020-2027 Sustainability Plan

Amgen data includes specific measurements for energy, water and waste obtained from our operations, representing 88 percent of Amgen's worldwide facility space based on total square feet. Included facilities are in Thousand Oaks, California, U.S.; West Greenwich, Rhode Island, U.S.; Louisville, Kentucky, U.S.; South San Francisco, California, U.S.; Cambridge and Woburn, Massachusetts, U.S.; Juncos, Puerto Rico; Burnaby, Canada; Breda, Netherlands; Dun Laoghaire, Ireland; Uxbridge and Cambridge, United Kingdom; São Paulo, Brazil; Yenibosna and Sekerpinar, Turkey; and Tuas, Singapore. Energy and carbon data for the remaining 12 percent of facility space is estimated based on building energy intensity factors and country specific emission factors. This includes leased buildings where we have operational control over building infrastructure, including utilities.

(b)

Direct onsite energy use results from the operation of equipment that is owned or controlled by Amgen. For facilities identified in note (a), data on the use of natural gas, propane and diesel in boilers, our combined heat and power turbine, and in heating, ventilation, and air conditioning systems is recorded from utility bills or purchase records. Data on the use of diesel in emergency generators is recorded from purchase records or meter readings and, in some cases, estimated from run-hours. Utility bills recorded in units of volume are converted to energy. Energy from emergency generators recorded as run-hours is estimated using the manufacturer's specified fuel-feed rate for each generator. For Amgen facilities where measurements are not obtained or available, usage is estimated from energy intensity factors based on building square footage.

(c)

Indirect onsite energy use results from purchased energy in the forms of electricity and steam. For facilities identified in note (a), data on the use of electricity and steam are recorded from utility bills. For Amgen facilities where measurements are not obtained or available, usage is estimated from energy intensity factors based on building square footage.

The fuel mix associated with the MBE methodology represents the fuel mix for energy that Amgen acquired through purchasing decisions. Non-specified sources of energy are recorded as Fossil Fuel.

(d)

In 2019, Amgen's facility in Breda, Netherlands installed a solar photovoltaic system.

(e)

Scope 1 carbon emissions result from direct energy sources defined in note (b); sales fleet; executive air fleet; and fugitive emissions from refrigerant losses, purchased carbon dioxide used for process operations and carbon dioxide emissions resulting from cell respiration in manufacturing processes and onsite wastewater treatment systems.

Carbon emissions from natural gas are calculated using the U.S. EPA's Center for Corporate Climate Leadership Emission Factors for Greenhouse Gas Inventories (1 April 2021) for all U.S. sites and locations not specifically listed below and for fuel consumed in fleet vehicles and executive air travel; the Intergovernmental Panel on Climate Change (IPCC) Canadian National Inventory Report (NIR) for Amgen's facility in Burnaby, Canada; the Ireland Country Specific Net Calorific Values and CO2 Emissions Factors for use in the Annual Installation Emissions Report- December 2021 for Amgen's facility in Dun Laoghaire, Ireland; The Netherlands IPCC NIR for Amgen's facility in Breda, Netherlands; and the U.K. DEFRA's Greenhouse gas reporting: conversion factors 2021 for Amgen's facilities in Uxbridge and Cambridge, United Kingdom.  Carbon emissions data from propane and diesel fuel sources are calculated using U.S. EPA's Center for Corporate Climate Leadership Emission Factors for Greenhouse Gas Inventories (1 April 2021). Carbon data from direct energy sources prior to 2011 were calculated using emission factors from the Greenhouse Gas Protocol Cross-Sector Tools-Stationary Combustion-V.1.0 (July 2009). Fugitive emissions include refrigerant losses, carbon dioxide equivalent emissions are calculated using their associated global warming potentials.

Carbon emissions from fugitive emissions were not reported prior to 2013

(f)

In 2021, Amgen's facility in West Greenwich, Rhode Island applied purchased carbon offsets to their Scope 1 emissions. Prior to 2021, Amgen did not record offsets for Scope 1 emissions

(g)

In 2021, Amgen is including emissions associated with non-greenhouse gas refrigerants (i.e., non-HFC). Prior to 2021, we did not report on carbon dioxide equivalent emissions for non-greenhouse gases

(h)

Scope 2 carbon market-based emissions (MBE) are a result of Amgen's procurement decisions on sourcing of indirect energy defined in note (c). For our facilities in Thousand Oaks, CA; West Greenwich, RI; Louisville, KY; Cambridge, MA; Breda, Netherlands; and Singapore we purchased in-country renewable energy certificates with zero greenhouse gas emissions. For our facilities in Dun Laoghaire, Ireland; Uxbridge, United Kingdom and Cambridge, United Kingdom we contract with our local energy providers for GreenPower Purchase Plans with zero greenhouse gas emissions. For facilities in San Francisco, California and Sao Paulo, Brazil we contract with our local energy providers to source electricity with low greenhouse gas emissions. Market-based emissions from our facility in Burnaby, Canada are calculated using local grid emission factors from the Intergovernmental Panel on Climate Change (IPCC) Canadian National Inventory Report (NIR). Market-based emissions from our facilities in Yenibosna and Sekerpinar, Turkey are calculated using the International Energy Agency's CO2 emissions from fuel combustion 2021. Market-based emissions from our facility in Woburn, Massachusetts are calculated using the U.S. EPA eGRID Summary Table 2020. Market-based emissions from our facility in Juncos, Puerto Rico are calculated using a combination of North American renewable energy certificates and the U.S. EPA eGRID Summary Table 2020. Carbon emissions from other Amgen locations and for sales fleet electric vehicle charging are calculated using country or regional emission factors from the International Energy Agency's CO2 emissions from fuel combustion 2021. Carbon data from purchased steam is calculated using an emission factor provided by the supplier for Amgen's facility in Cambridge, Massachusetts. For base year 2007 and 2012 Amgen has not calculated separate market-based or location-based emissions. Carbon emissions for these years are reported as both our market-based and location-based emissions. Prior to 2021, electricity consumption of electric vehicle charging was de minimis and not reported.

(i)

Scope 2 carbon location-based emissions (LBE) are calculated using local or regional emission factors for purchased electricity and steam. For facilities in the United States of America and Puerto Rico, we use the U.S. EPA eGRID Summary Tables 2020; for Burnaby, Canada we use the Intergovernmental Panel on Climate Change's (IPCC) Canadian National Inventory Report (NIR); for our facilities in Cambridge and Uxbridge United Kingdom we use the U.K. DEFRA's Greenhouse gas reporting: conversion factors 2021, for all other locations we use the International Energy Agency's CO2 emissions from fuel combustion 2021. LBE carbon data from purchased steam is calculated using the U.S. Energy Star® Portfolio Manager® Technical Reference for district steam.

(j)

Measurement and verification of carbon conservation and reduction projects are based on adaptation of the International Performance Measurement and Verification Protocol (IPMVP). Project measurements are conducted using reasonable means, including direct measurements and scientific estimations as appropriate. Values reported in 2012, represent year-over-year, cumulative and continuing avoidance based on a 2007 baseline for Amgen's 2012 Environmental Sustainability Program (years 2008-2012); values reported in 2019 represent year-over-year, cumulative and continuing avoidance based on a 2012 baseline for Amgen's 2020 Environmental Sustainability Program (years 2013-2019); and a 2019 baseline for Amgen's 2027 Environmental Sustainability Program (years 2020-2027). NOTE: 2020 Environmental Sustainability Program's conservation targets were achieved ahead of schedule and the program was closed in 2019.

(k)

Scope 3 – Upstream
Scope 3 carbon emissions are a consequence of the activities of the company but occur from sources not owned or controlled by the company.

Scope 3 carbon emissions that are currently tracked include emissions from Amgen's purchased goods and services, capital goods, fuel-related activities, upstream material transportation, waste generated in operations, commercial business travel (air and rail), and staff commuting. Carbon emissions for Scope 3 Purchased Goods and Services and from Scope 3 Capital Goods are calculated using spend data and the Greenhouse Gas Protocols Scope 3 Evaluator tool. Carbon emissions from Scope 3 Fuel- and Energy-related Activities are calculated using the U.K. DEFRA's Greenhouse gas reporting: conversion factors 2021. Carbon emissions from Scope 3 Upstream Transportation and Distribution have been provided by Amgen's transportation carriers using their own specific methods or calculated using carrier data. Carbon emissions from Scope 3 Waste Generated in Operations is calculated using the U.K. DEFRA's Greenhouse gas reporting: conversion factors 2021. Carbon emissions from Scope 3 Business Travel are calculated by Amgen's travel provider for air travel and internal information for hotel stays and rental car miles. Carbon emissions from Scope 3 Employee Commuting are calculated using the Global Fuel Economy Initiative's International Comparison of Light-Duty Vehicle Fuel Economy. Carbon emissions from upstream leased assets are included in Amgen's Scope 1 and 2 Emissions accounting

See Amgen's CDP climate change disclosures for additional Scope 3 information.

(l)

Measurement and verification of water conservation and reduction projects are based on adaptation of the International Performance Measurement and Verification Protocol (IPMVP). Project measurements are conducted using reasonable means, including direct measurements and scientific estimations as appropriate. Values reported in 2012, represent year-over-year, cumulative and continuing avoidance based on a 2007 baseline for Amgen's 2012 Environmental Sustainability Program (years 2008-2012); values reported in 2019 represent year-over-year, cumulative and continuing avoidance based on a 2012 baseline for Amgen's 2020 Environmental Sustainability Program (years 2013-2019); and a 2019 baseline for Amgen's 2027 Environmental Sustainability Program (years 2020-2027). NOTE: 2020 Environmental Sustainability Program's conservation targets were achieved ahead of schedule and the program was closed in 2019.

(m)

The recycle rate is the total routine recycled, composted and reused weight divided by the total weight of routine waste.

(n)

Treatment means the physical, thermal, chemical or biological processes that change the characteristics of the waste in order to reduce its volume or hazardous nature, facilitate its handling or enhance recovery.

(o)

Nonroutine waste constitutes waste generated outside the normal operations of our facilities and consists mainly of construction and demolition waste.

(p)

Measurement and verification of waste conservation and reduction projects are based on adaptation of the International Performance Measurement and Verification Protocol (IPMVP). Project measurements are conducted using reasonable means, including direct measurements and scientific estimations as appropriate. Amgen's 2027 Plan focusses on a reduction in waste disposed (i.e., waste sent to landfill, treatment or incineration without energy recovery) from base year 2019 and differs from previous waste reduction metrics. For data on historical waste reduction projects, please see Archived Reports

(q)

Environmental notices of violation (NOVs) reported that resulted from agency inspections.