Summary of Data

(a)

Amgen data includes specific measurements for energy, water and waste obtained from our operations, representing 88 percent of Amgen's worldwide facility space based on total square feet. Included facilities are in Thousand Oaks, California, U.S.; West Greenwich, Rhode Island, U.S.; Louisville, Kentucky, U.S.; South San Francisco, California, U.S.; Cambridge and Woburn, Massachusetts, U.S.; Juncos, Puerto Rico; Burnaby, Canada; Breda, Netherlands; Dun Laoghaire, Ireland; Uxbridge and Cambridge, United Kingdom; São Paulo, Brazil; Yenibosna and Sekerpinar, Turkey; and Tuas, Singapore. Energy and carbon data for the remaining 12 percent of facility space is estimated based on building energy intensity factors and country specific emission factors. This includes leased buildings where we have operational control over building infrastructure, including utilities.

(b)

Measurement and verification of conservation and reduction projects for energy and carbon, water and waste are based on adaptation of the International Performance Measurement and Verification Protocol (IPMVP). Project measurements are conducted using reasonable means, including direct measurements and scientific estimations as appropriate. Values for conservation and reduction projects represent year-over-year, cumulative and continuing avoidance based on a 2007 baseline, then re-baselined in 2012 to match the next-generation 2020 Target design.

(c)

Immaterial changes to 2007–2018 data may have occurred due to refinements in calculations. All changes have been confirmed through a documented change control process.

(d)

Direct onsite energy use results from the operation of equipment that is owned or controlled by Amgen. For facilities identified in note (a), data on the use of natural gas, propane and diesel in boilers, furnaces and HVAC is recorded from utility bills or purchase records. Data on the use of diesel in emergency generators is recorded from purchase records or meter readings and, in some cases, estimated from run-hours. Utility bills recorded in units of volume are converted to energy. Energy from emergency generators recorded as run-hours is estimated using the manufacturer's specified fuel-feed rate for each generator. For Amgen facilities where measurements are not obtained or available, usage is estimated from energy intensity factors based on building square footage.

(e)

Indirect onsite energy use results from purchased energy in the forms of electricity and steam. For facilities identified in note (a), data on the use of electricity and steam are recorded from utility bills. For Amgen facilities where measurements are not obtained or available, usage is estimated from energy intensity factors based on building square footage.

(f)

Scope 1 carbon emissions result from direct energy sources defined in note (d). Additional Scope 1 Carbon emissions from sales fleet; executive air fleet; fugitive emissions from chillers, coolers and HVAC; carbon dioxide used for neutralization; and carbon dioxide resulting from cell respiration in manufacturing processes and biological wastewater treatment are found in the Other Carbon category in this data summary. Carbon emissions from natural gas sources are calculated using the U.S. EPA's Center for Corporate Climate Leadership Emission Factors for Greenhouse Gas Inventories (9 March 2018) for all U.S. sites and locations not specifically listed below; the 2018 B.C. Best Practices Methodology for Quantifying Greenhouse Gas Emissions for Amgen's facility in Burnaby, Canada; the Ireland Country Specific Net Calorific Values and CO2 Emissions Factors for use in the Annual Installation Emissions Report- 2019 for Amgen’s facility in Dun Laoghaire, Ireland; The Netherlands: list of fuels and standard CO2 emission factors version of January 2019 for Amgen’s facility in Breda, Netherlands; and the U.K. Defra's Greenhouse gas reporting: conversion factors 2019 for Amgen’s facilities in Uxbridge and Cambridge, United Kingdom. Carbon emissions data from propane and diesel fuel sources are calculated using U.S. EPA's Center for Corporate Climate Leadership Emission Factors for Greenhouse Gas Inventories (9 March 2018). Carbon data from direct energy sources prior to 2011 were calculated using emission factors from the Greenhouse Gas Protocol Cross-Sector Tools-Stationary Combustion-V.1.0 (July 2009).

(g)

Scope 2 carbon market-based emissions result from indirect energy sources defined in note (e). Carbon emissions from purchased electricity are calculated using emission factors from U.S. EPA eGRID Summary Tables 2018 for Amgen’s facilities in Thousand Oaks, California and Louisville, Kentucky. Amgen’s facility in San Francisco, California; Woburn and Cambridge, Massachusetts; West Greenwich, Rhode Island; Dun Laoghaire, Ireland; and Cambridge and Uxbridge United Kingdom carbon emissions are calculated using supplier specific emission factors. Amgen's facility in Puerto Rico are calculated using The Climate Registry Emission Factors for "U.S. territories (not an eGRID Region)" (May 1, 2018). Carbon emissions from purchased electricity for Amgen's facility in British Columbia, Canada are calculated using regional emission factors. Carbon emissions from purchased electricity for Amgen's Netherlands facility are covered by a renewable energy certificate. Carbon emissions from purchased electricity for Amgen's facility in Singapore are calculated using emission factors from the International Energy Agency's CO2 emissions from fuel combustion 2019 and a renewable energy certificate covering electricity purchased during the fourth quarter 2019. Carbon emissions from Amgen’s remaining locations (including Brazil and Turkey) are calculated using emission factors from the International Energy Agency's CO2 emissions from fuel combustion 2019. Carbon data from purchased steam is calculated using an emission factor provided by the supplier for Amgen's facility in Cambridge, Massachusetts. Carbon data from indirect energy sources prior to 2011 were calculated using emission factors from U.S. EPA eGRID2007 Version 1.1 for U.S. facilities.

(h)

The Other Carbon category contains additional Scope 1 and Scope 3 carbon emissions. Carbon emissions from our executive air fleet and sales fleet are calculated using emission factors from the U.S. EPA's Center for Corporate Climate Leadership Emission Factors for Greenhouse Gas Inventories (9 March 2018). U.S. sales fleet fuel usage and mileage data are collected at the pump for Amgen leased vehicles. Beginning in 2017, sales fleet incorporated international fleets, and in 2018 estimates were included for additional international locations and field workers operating long-term rental vehicles. Fugitive emissions from process equipment (e.g., refrigerant from refrigeration and HVAC equipment) are calculated using emission factors from the Intergovernmental Panel on Climate Change. Processes are in place to maintain chillers, coolers and HVAC equipment to prevent unintended emissions. Beginning in 2019 fugitive emissions include carbon emissions from purchased carbon dioxide and from on-site cell respiration in manufacturing and wastewater treatment operations. Scope 3 carbon emissions are a consequence of the activities of the company but occur from sources not owned or controlled by the company. Scope 3 carbon emissions that are currently tracked include emissions from Amgen's purchased goods and services, capital goods, fuel-related activities, upstream material transportation, waste generated in operations, commercial business travel (air and rail), and staff commuting.

(i)

Carbon emissions for Scope 3 Purchased Goods and Services and from Scope 3 Capital Goods are calculated using spend data and the Greenhouse Gas Protocols Scope 3 Evaluator tool. Carbon emissions from Scope 3 Fuel- and Energy-related Activities are calculated using the U.K. Defra's Greenhouse gas reporting: conversion factors 2019. Carbon emissions from Scope 3 Upstream Transportation and Distribution have been provided by Amgen’s transportation carriers using their own specific methods or calculated using carrier data and emission factors from the U.S. EPA's Center for Corporate Climate Leadership Emission Factors for Greenhouse Gas Inventories (9 March 2018). Carbon emissions from Scope 3 Waste Generated in Operations is calculated using the U.K. Defra's Greenhouse gas reporting: conversion factors 2019. Carbon emissions from Scope 3 Business Travel are calculated by Amgen's travel provider. Carbon emissions Scope 3 Employee Commuting are calculated using the Global Fuel Economy Initiative’s International Comparison of Light-Duty Vehicle Fuel Economy 2005-2015.

(j)

Carbon emissions from commercial business travel was not tracked in 2007 or 2008. Carbon emissions from material transportation was not tracked from 2007 to 2011. The accuracy of carbon emissions tracking from fugitive refrigerant emissions improved in 2013 and will now be reported going forward. Carbon emissions from staff commuting and waste disposal was not tracked prior to 2017. Carbon emissions from purchased goods and services, capital goods, and fuel-related activities were not tracked prior to 2018.

(k)

Immaterial discrepancy between values for total water fate and total water withdrawal is due to rounding and compilation of individual facility totals.

(l)

The recycle rate is the total routine recycled, composted and reused weight divided by the total weight of routine waste.

(m)

Treatment means the physical, thermal, chemical or biological processes that change the characteristics of the waste in order to reduce its volume or hazardous nature, facilitate its handling or enhance recovery.

(n)

Nonroutine waste constitutes waste generated outside the normal operations of our facilities and consists mainly of construction and demolition waste.

(o)

Emissions and fuel use avoided are the result of improvements in fleet efficiency from years 2007 through 2012 based on a 2007 baseline and years 2013+ based on a 2012 baseline.

(p)

Environmental notices of violation (NOVs) reported that resulted from agency inspections.